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目的分析重庆市艾滋病病毒感染者(HIV)和获得性免疫缺陷综合征(acquired immune deficiency syndrome,AIDS)患者(简称HIV/AIDS患者)合并感染乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)状况。方法利用《艾滋病综合防治系统——抗病毒治疗管理》数据库,回顾收集重庆市2004-2015年HIV/AIDS治疗患者基本情况和HBs Ag、Anti-HCV实验室检测结果,利用SPSS 19.0统计软件进行统计分析。结果截至2015年12月31日,重庆市HIV/AIDS患者中HBs Ag和(或)Anti-HCV总检测率55.1%(11 231/20 397),其中HBs Ag和Anti-HCV都进行检测的患者有9 307例。HIV/HBV、HIV/HBV/HCV、HIV/HCV合并感染的比例分别为9.8%、0.9%、4.5%。HIV/HCV合并感染在30~45岁年龄段构成比最高;HIV/HBV合并感染在男性中构成比最高,与HIV单纯感染组比较,差异均具有统计学意义(P<0.05)。HIV/HBV合并感染及HIV单纯感染均在性传播中构成比最高,差异无统计学意义(P=0.177);HIV/HCV和HIV/HBV/HCV合并感染在静脉吸毒中构成比最高,与HIV单纯感染比较,差异具有统计学意义(P<0.05)。主城9区中HIV/AIDS患者及合并感染患者比例最高。合并感染组病死率均高于HIV单纯感染组,HIV/HBV/HCV组病死率最高。结论重庆市HIV/AIDS患者中HBs Ag、Anti-HCV检测率较低,不同感染模式具有不同的流行病学特征,且合并感染的病死率较高,需要进一步加强对重庆市HIV/AIDS患者中HBV、HCV合并感染检测率和治疗情况的管理。
Objective To analyze the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis C virus (HCV) in Chongqing patients with acquired immunodeficiency syndrome (HIV) and AIDS (patients with HIV / AIDS) )situation. Methods Using the database of “Integrated HIV / AIDS Prevention and Control System - Antiviral Therapy Management”, the basic situation of HIV / AIDS patients in Chongqing from 2004 to 2015 and the results of HBsAg and Anti-HCV laboratory tests were collected and analyzed by SPSS 19.0 statistical software analysis. Results As of December 31, 2015, the overall detection rate of HBs Ag and / or Anti-HCV in Chongqing was 55.1% (11 231/20 397), in patients with both HBs Ag and Anti-HCV There are 9,307 cases. The rates of HIV / HBV, HIV / HBV / HCV and HIV / HCV co-infection were 9.8%, 0.9% and 4.5% respectively. The HIV / HCV co-infection was the highest in the age group of 30-45 years. The HIV / HBV co-infection was the highest in males and the difference was statistically significant (P <0.05) compared with the HIV-only infection group. HIV / HBV co-infection and HIV infection alone had the highest proportion of sexually transmitted infections (P = 0.177). HIV / HCV and HIV / HBV / HCV co-infection had the highest proportion of intravenous drug use, Simple infection, the difference was statistically significant (P <0.05). The proportion of HIV / AIDS patients and the co-infected patients in the 9 districts of the main city is the highest. Case fatality rate was higher in HIV infection group than in HIV infection group, with the highest mortality rate in HIV / HBV / HCV group. Conclusions The detection rate of HBs Ag and Anti-HCV in HIV / AIDS patients in Chongqing is low. Different infection patterns have different epidemiological characteristics, and the mortality rate of combined infection is high. Therefore, it is necessary to further strengthen the screening of HIV / AIDS patients in Chongqing Management of detection rates and treatment of HBV and HCV coinfection.