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目的 探讨良性前列腺增生症 (BPH)血清前列腺特异性抗原 (PSA)的临床特点。方法 回顾性分析 111例住院待术和 45 7例普查中诊断的BPH的PSA、PSAD情况。结果 手术组和普查组的PSA和PSAD值分别为 6 .5 8± 7.49ng/ml、0 .12± 0 .15和 3.77± 4.6 0ng/ml、0 .9± 0 .11。普查组的PSA值与患者年龄呈显著正相关 (P <0 .0 1) ,而手术组无明显相关性 (P >0 .0 5 )。留置导尿的BPH其PSA(7.6 9± 8.0 5ng/ml,P <0 .0 1)和PSAD(0 .13± 0 .17,P <0 .0 1)显著高于非留置导尿者。而直肠指检触及前列腺表面结节者其PSA值 (6 .72± 5 .81ng/ml)也明显高于无结节的患者 (P <0 .0 1)。结论 BPH患者血清PSA个体差异较大 ,留置导尿及前列腺结节均可能引起PSA升高 ,在临床评估中需予综合考虑。
Objective To investigate the clinical features of serum prostate specific antigen (PSA) in benign prostatic hyperplasia (BPH). Methods A retrospective analysis of 111 cases of hospitalized patients and 457 censuses in the diagnosis of BPH PSA, PSAD situation. Results The PSA and PSAD values of the surgery group and the census group were respectively 6. 58 ± 7.49 ng / ml, 0.12 ± 0.15 and 3.77 ± 4.6 0 ng / ml, 0.9 ± 0.11. There was a significant positive correlation between the PSA value and the patient’s age in the census group (P <0.01), but no significant correlation between the PSA and the operation group (P> 0.05). In BPH patients with indwelling catheterization, PSA (7.69 ± 8.0 5ng / ml, P <0.01) and PSAD (0.13 ± 0.17, P <0.01) were significantly higher than those without indwelling catheterization. The PSA value of rectal finger touching the surface of nodule of prostate was also significantly higher than that of nodules (6 .72 ± 5 .81 ng / ml) (P <0.01). Conclusions The serum PSA in BPH patients is quite different. Indwelling catheterization and prostatic nodules may cause PSA increase, which should be considered comprehensively in clinical evaluation.