报道３６例脊索瘤的临床病理改变，颅内２３例，颅外１３例。选用５种抗体对其中３１例做免疫组化检测，阳性率Ｓ－１００为９０％，Ｋｅａｔｉｎ和Ｖｉｍｅｎｔｉｎ为１００％，ＥＭＡ为９３．５％，ＣＥＡ为６％。５例做透射电镜观察，显示胞质小器复合体和桥粒连接。指出本瘤源于胚胎残余脊索，此种残存常发生异位，生物学行为属于恶性。其病理易与５类肿瘤发生混淆，并提出了鉴别要点 The clinicopathological changes of 36 cases of chordoma were reported, including 23 intracranial and 13 extracranial. The immunohistochemical method was used to detect 31 of them with 5 antibodies. The positive rate was 90% for S-100, 100% for Keatin and Vimentin, 93.5% for EMA, and 6% for CEA. Transmission electron microscopy was performed in 5 cases, showing cytoplasmic organ complex and desmosomes. It was pointed out that this tumor originated from the remnant spinal cord of the embryo, and this kind of remnant often occurred ectopically, and its biological behavior was malignant. Its pathology is easy to be confused with 5 kinds of tumors, and the key points for differentiation