糖尿病是损害人类健康的一种常见疾病,其最常见的并发症为糖尿病性神经病理性痛。近年来研究发现,小胶质细胞在糖尿病性神经病理性痛的形成中有重要作用。糖尿病性神经病变发生后,诱导小胶质细胞产生缓激肽B1受体(kinin B1 receptors,B1R),进而促使小胶质细胞的激活、迁移,最终导致糖尿病性神经病理性痛产生。该文综述了小胶质细胞B1R在糖尿病性神经病理性痛中的作用。 Diabetes is a common disease that damages human health. The most common complication is diabetic neuropathic pain. In recent years, studies have found that microglia play an important role in the formation of diabetic neuropathic pain. After diabetic neuropathy, it induces microglial cells to produce kinin B1 receptors (B1R), which in turn leads to the activation and migration of microglia and eventually leads to the production of diabetic neuropathic pain. This article reviews the role of microglia B1R in diabetic neuropathic pain.