论文部分内容阅读
目的探讨肿瘤出芽与结肠腺癌恶性生物学行为的关系及其临床价值。方法应用HE染色在光镜下观察2005年1月—2011年12月136例结肠腺癌患者标本组织中肿瘤出芽情况,并随访患者,记录肿瘤部位、分化程度、浸润深度、淋巴结转移、淋巴管浸润、TNM分期等临床病理指标,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果 136例结肠腺癌患者标本中有71例发生肿瘤出芽,出芽率为52.21%。有淋巴结转移者、淋巴管浸润者的肿瘤出芽率(66.13%、66.67%)明显高于无淋巴结转移者、淋巴管浸润者(40.54%、42.68%),差异有统计学意义(P<0.05);肿瘤TNM分期越高,肿瘤出芽率越高,有肿瘤出芽者早期复发率(36.62%)明显高于无肿瘤出芽者(13.85%),差异有统计学意义(P<0.05)。不同肿瘤发生部位、分化程度和浸润深度的肿瘤出芽率差异无统计学意义(P>0.05)。结论肿瘤出芽是提示结肠腺癌侵袭性生物学行为的重要形态特征,有肿瘤出芽的结肠腺癌患者早期复发多见。
Objective To investigate the relationship between tumor budding and malignant biological behavior of colon adenocarcinoma and its clinical value. Methods HE staining was used to observe the tumor sprouting in 136 specimens of colon adenocarcinoma from January 2005 to December 2011. The tumor location, differentiation, depth of invasion, lymph node metastasis and lymphatic vessels Infiltration, TNM staging and other clinical and pathological indicators, count data using χ2 test, P <0.05 for the difference was statistically significant. Results Tumor outgrowth occurred in 71 of 136 patients with colon adenocarcinoma, with a sprouting rate of 52.21%. The rate of tumor budding (66.13%, 66.67%) in patients with lymph node metastasis and lymphatic invasion was significantly higher than those without lymph node metastasis (40.54%, 42.68%), the difference was statistically significant (P0.05) The higher TNM stage of tumor was, the higher the rate of tumor budding was. The early recurrence rate of tumor budding was 36.62%, which was significantly higher than that of tumor-free budding (13.85%) (P <0.05). There was no significant difference in tumor budding rate between different tumor sites, degree of differentiation and depth of invasion (P> 0.05). Conclusions Tumor sprouting is an important morphological feature that suggests aggressive biological behavior of colon adenocarcinoma. Early recurrence of colon adenocarcinoma with tumor sprouting is more common.