胰腺癌肿动脉内化疗时用血管阻断器使肝或胰血流暂时再分布(英)

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肝肿瘤主要由动脉供血,去动脉供应仅暂时阻止其生长,因为侧枝循环可很快形成.作者置入一可充盈气囊的阻断器,包裹在选定的动脉周围,产生暂时缺血以影响肿瘤的生长而无侧枝循环的形成.原型硅 酮血管阻断器象一微型血管止血带,13×35mm或20×70mm分别用于动脉或门静脉.阻断器在术中置放,用非吸收性缝线缝合,以金属夹固定,气囊导管引出至皮下处.1例患不能手术切除的肝细胞癌,自胃十二指肠动脉插管供区域性化疗之用,在肝左动脉(源自胃十二指肠动脉之前)近端的肝总动脉绕一血管阻断器,充气气囊后从插管的血流逆流入肝总动脉和肝左动脉,由此可以灌注全肝.在另2例女性和1例男性胰腺癌,手术不能切除而施行了远端胃切除、胃空肠吻合、胆囊切除和胆肠吻合以缓解十二指肠和胆道梗阻.从切断的胃左动脉将化疗导管插入腹腔动脉干,血管阻断器分别置于远端脾动脉和肝固有动脉,阻断上述血管可限制其血流.每周给5Fu 250mg、丝裂霉素4mg和0.1mg肾上腺素,3~5周为一疗程,每一病人给1~3疗程的区域性化疗,术后1月开始化疗,使用血管阻断器.稍伴有恶心和食欲减退1天,除高温灌注时外无疼痛.第1疗程后给1~3疗程外照射,每1疗程2周,共20Gy.1例原有的中度腹痛化疗 Liver tumors are mainly supplied by arteries, and dearterialization only temporarily prevents their growth because collateral circulation can develop rapidly. The author places a balloon-fillable blocker that wraps around the selected artery and causes temporary ischemia to affect The growth of the tumor without the formation of collateral circulation. Prototype silicone vascular blocker like a microvascular tourniquet, 13 × 35mm or 20 × 70mm, respectively, for the arterial or portal vein. Blocker placed in the surgery, with non-absorbing The suture was sutured and fixed with a metal clip. The balloon catheter was withdrawn to the subcutaneous site. One patient had unresectable hepatocellular carcinoma, and gastroduodenal artery catheterization was used for regional chemotherapy in the left hepatic artery (source From the gastroduodenal artery) the proximal common hepatic artery is bypassed by a vascular blocker, and the inflated balloon is then retrogradely flowed from the cannula into the common hepatic artery and the left hepatic artery, thereby perfusing the whole liver. Two cases of female and 1 case of male pancreatic cancer were operated without distal gastrectomy, gastrojejunostomy, cholecystectomy, and biliary-enteric anastomosis to relieve duodenal and bile duct obstruction. The left gastric artery was cut from the left gastric artery to the chemotherapy catheter. The celiac artery was inserted and the vascular blockers were placed End splenic artery and hepatic artery, blocking the blood vessels can limit their blood flow. Weekly to 5Fu 250mg, mitomycin 4mg and 0.1mg epinephrine, 3 to 5 weeks for a course of treatment, each patient to 1 to 3 Treatment of regional chemotherapy, chemotherapy started 1 month after surgery, use of vascular blockers. Slightly accompanied by nausea and loss of appetite for 1 day, in addition to high temperature perfusion no pain. After the first course of treatment to 1 to 3 courses of external exposure, each 1 course of 2 weeks, a total of 20 Gy. 1 case of the original moderate abdominal pain chemotherapy
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