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目的:探讨血塞通药品不良反应发生的一般规律及特点,为临床合理用药提供参考。方法:采用回顾性研究方法,对2011年10月至2012年9月上海市宝山区药品不良反应监测中心收集到的血塞通药品不良反应报告进行统计和分析。结果:血塞通药品所致不良反应84例,女性多于男性,且60岁以上患者发生率高,占77.4%;发生不良反应时间在给药后10-30min和31-60min的比例较高,分别为39.3%和34.5%;不良反应累及的系统-器官主要有全身性损害33例(27.3%)、中枢及外周神经损害30例(24.8%)、皮肤过敏反应22例(18.2%)。结论:临床医生、药师、护士应了解血塞通药品所致不良反应的规律和特点,加强其用药监测,以减少不良反应的发生,确保用药安全。
Objective: To explore the general rules and characteristics of Xuesaitong’s adverse drug reactions and to provide reference for clinical rational drug use. Methods: A retrospective study was conducted to analyze and analyze the data of Xuesaitong drug adverse reactions collected from Shanghai Baoshan District ADR Monitoring Center from October 2011 to September 2012. Results: Xuesaitong drug-induced adverse reactions in 84 cases, more women than men, and over the age of 60 patients with a high incidence, accounting for 77.4%; adverse reaction time after administration of 10-30min and 31-60min higher proportion , Which were 39.3% and 34.5% respectively. The systemic-organ involvement in adverse reactions included 33 cases (27.3%) with systemic injury, 30 cases (24.8%) with central and peripheral nerve damage and 22 cases (18.2%) with skin allergic reaction. Conclusion: Clinicians, pharmacists and nurses should understand the rules and characteristics of Xuesaitong drug-induced adverse reactions, and strengthen the monitoring of drug use to reduce the incidence of adverse reactions and ensure drug safety.