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肾移植受者由于接受免疫抑制药物治疗使其对感染的易感性增加。流感病毒感染时易造成较重的肺部併发症或直接的肾损伤,也可导致异体移植肾的排斥反应。所以对接受肾移殖者应认真预防病毒感染。作者在1976年的一次猪流感暴发期间,对一组应用了免疫抑制疗法的肾移植患者,研究了接种流感疫苗后的抗体反应;以及移植肾的功能改变。对照组为15名健康的医院工作人员。肾移植组共20例,年龄18～58岁。移植期为2～54个月。所有研究对象均接种了双价A型流感病毒疫苗0.5毫升。接种前、后4～5周各测定血凝—抑制滴度。反应的判断标准按接种疫苗后。抗体增加4倍为满意。结果,对照组15例接种后分别增高4～16倍,肾移植组20例中,仅12例抗体滴度增高4倍或以上,3例增高2倍,5例无反
Renal transplant recipients have increased susceptibility to infection due to immunosuppressive drug treatment. Influenza virus infection easily lead to severe pulmonary complications or direct renal damage, can also lead to allograft rejection of kidney. Therefore, renal transplant recipients should carefully prevent viral infection. During a swine flu outbreak in 1976, the authors studied the antibody response following influenza vaccination in a group of kidney transplant recipients with immunosuppressive therapy; and functional changes in the transplant kidneys. The control group consisted of 15 healthy hospital staff. A total of 20 cases of renal transplantation group, aged 18 to 58 years. Transplantation period of 2 to 54 months. All subjects were vaccinated with the bivalent influenza A virus vaccine 0.5 ml. Before inoculation, 4 to 5 weeks after the determination of blood coagulation - inhibition titers. Response to the criteria by vaccination. Antibody 4 times more satisfied. As a result, in the control group, 15 cases were increased by 4 to 16 times after inoculation. Among the 20 cases in the renal transplantation group, only 12 cases showed an increase in antibody titer of 4 times or more, 3 cases increased 2 times and 5 cases without any reaction