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痢特灵是一种目前临床仍在较广泛应用的抗痢疾药物。据药理学杂志记载,该药副作用有恶心,呕吐,多发性神经炎及过敏反应(皮疹、药物热、哮喘、肺浸润、头痛,直立性低血压,低血糖等)。对眼部损害的报导尚未见到。我们曾遇到15例服用痢特灵后造成眼部损害,其表现繁多,损害严重,失明者占绝大多数。现特将其中毒后的眼部改变介绍如下。中毒后,起病缓慢,进展迅速,发病均不在服药当日。十余例患者起病均在停药后3—10日。一经发病,视力很快下降,病变日渐加重。球结膜及睑结膜充血、睑结膜弥漫性糜烂。眼球运动受限。最后睑球粘连,角膜混浊.有限底病变时,外眼部正常。有时发生球后视神经炎和视神经网膜炎,以及视乳头水肿。
Furazolidone is a kind of anti-dysentery drug still widely used in clinic. According to the Journal of Pharmacology, the side effects of the drug are nausea, vomiting, polyneuritis and allergic reactions (rashes, drug fever, asthma, pulmonary infiltrates, headaches, orthostatic hypotension, hypoglycemia, etc.). Eye damage reports have not been seen. We have encountered 15 cases of eye damage caused by taking furazolidone, the performance of many, serious damage, blindness accounted for the overwhelming majority. Now it will be poisoned after the eye changes are described below. After poisoning, the onset is slow, rapid progress, the incidence is not on the day of medication. More than a dozen cases of patients were discontinued 3-10 days after. Upon onset, vision soon dropped, the disease is getting worse. Bulbar conjunctiva and conjunctival hyperemia, conjunctival diffuse erosion. Eye movement is limited. Last symblepharon, corneal opacity. Limited at the end of disease, the outer eye is normal. Posterior optic neuritis and optic neuritis, and papilledema sometimes occur.