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目的研究心肌酶水平与新生儿窒息缺氧危害相关性。方法选择2015年1月至2016年4月新生儿窒息患者64例为观察组,另选同期健康新生儿50例为对照组。根据窒息分级得到轻度窒息患儿37例,重度窒息患儿27例。对比几组患儿心肌酶水平,并分析心肌酶水平与新生儿窒息缺氧危害的相关性。结果观察组天门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)均显著高于对照组,而轻度窒息组AST、CK、CK-MB、LDH均显著低于重度窒息组;并且轻度窒息组中出现心肌酶升高、合并心肌损伤病患比例均显著低于重度窒息组;差异均有统计学意义(P均<0.05)。最后通过相关性分析得到心肌酶中AST、CK、CK-MB、LDH与新生儿窒息缺氧均呈显著的正相关(r=0.784,P<0.001;r=0.819,P<0.001;r=0.728,P<0.001;r=0.803,P<0.001)。结论血清心肌酶水平的检测是诊断新生儿窒息的敏感指标,为新生儿窒息早治疗提供临床依据。
Objective To study the correlation between myocardial enzyme level and neonatal asphyxia and hypoxia. Methods Sixty-four neonates with asphyxia from January 2015 to April 2016 were selected as observation group and 50 healthy newborn children as control group. According to asphyxia, 37 cases of mild asphyxia and 27 cases of severe asphyxia were obtained. Compare several groups of children with myocardial enzyme levels, and analyze the correlation between myocardial enzyme levels and neonatal asphyxia hypoxia. Results Aspartate aminotransferase (AST), creatine kinase (CK), creatine kinase CK (CK-MB) and lactate dehydrogenase (LDH) in the observation group were significantly higher than those in the control group The levels of AST, CK, CK-MB and LDH in asphyxia group were significantly lower than those in severe asphyxia group, and those in mild asphyxia group were higher than those in severe asphyxia group. The differences were statistically significant Significance (P <0.05). Correlation analysis showed that there was a significant positive correlation between AST, CK, CK-MB, LDH and neonatal asphyxia (r = 0.784, P <0.001; r = 0.819, , P <0.001; r = 0.803, P <0.001). Conclusion The detection of serum myocardial enzyme level is a sensitive indicator of neonatal asphyxia, providing a clinical basis for early treatment of neonatal asphyxia.