目的评价伐昔洛韦在防治三叉神经痛球囊压迫术术后疱疹中的疗效。方法 1680例原发性三叉神经痛患者,按收治时间不同分为常规治疗组(586例)、阿昔洛韦组(573例)及伐昔洛韦组(521例)。患者均采用球囊压迫术治疗,针对术后疱疹,分别给予常规治疗、阿昔洛韦及伐昔洛韦治疗。观察三组患者药物疗效。结果常规治疗组术后65.53%患者出现疱疹,并且分布广泛,口周、面颊及眼睑都有累及,持续时间(10.21±2.32)d;阿昔洛韦组术后24.08%患者出现疱疹,主要分布在口周及面颊,持续时间(7.13±1.57)d;伐昔洛韦组术后10.17%患者出现疱疹,主要分布在口周,持续时间(3.56±1.35)d。见表2,3。与常规治疗组比较,阿昔洛韦组与伐昔洛韦组效果更优(P<0.01);与阿昔洛韦组比较,伐昔洛韦组效果更优(P=0.008<0.05)。结论伐昔洛韦在防治三叉神经痛球囊压迫术术后疱疹中的疗效确切,效果优于阿昔洛韦,值得在临床治疗中推广应用。 Objective To evaluate the efficacy of valaciclovir in the prevention and treatment of herpes zoster after balloon compression of trigeminal neuralgia. Methods A total of 1680 patients with primary trigeminal neuralgia were divided into routine treatment group (586 cases), acyclovir group (573 cases) and valaciclovir group (521 cases) according to the time of treatment. Patients were treated with balloon compression surgery, for the treatment of herpes were given conventional treatment, acyclovir and valacyclovir treatment. Three groups of patients observed drug efficacy. Results In the conventional treatment group, 65.53% of the patients showed herpes and were distributed widely, with perioral, cheek and eyelid involvement for a duration of (10.21 ± 2.32) d. Herpes was found in 24.08% of the patients in the acyclovir group after operation, the main distribution Peripheral and cheek durations were (7.13 ± 1.57) d. Herpes was found in 10.17% of patients in valaciclovir group, which was mainly located in the perioral area with a duration of (3.56 ± 1.35) days. See Table 2 and 3. Compared with the conventional treatment group, the acyclovir group and the valaciclovir group were more effective (P <0.01). Compared with the acyclovir group, the valacyclovir group was more effective (P = 0.008 <0.05). Conclusion Valacyclovir in the prevention and treatment of trigeminal neuralgia after balloon compression surgery herpes curative effect is accurate, the effect is better than acyclovir, it is worth in the clinical treatment of the promotion and application.