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选择糖尿病患者 48例 ,同时测定血糖值、HbA1c水平、AR、SOD活性、NO和神经传导速度 ,统计分析上述各指标的相关性。结果直线回归分析发现神经传导速度与血糖、HbA1c水平、AR活性明显负相关 (P <0 0 1 ) ,与SOD活性、NO水平明显正相关 (P <0 0 1 ) ;将 48例患者按神经传导速度分为三组 ,血糖、HbA1c、AR、SOD、NO轻、中组差异显著 (P <0 0 1 ) ,而中、重组无明显差异 (P >0 0 5 )。结论高血糖所致的蛋白非酶糖化、多元醇通路活性升高、氧化应激对早期DN的发生、发展起重要作用 ,NO可能参与糖尿病神经病变的形成
Forty-eight patients with diabetes mellitus were selected and their blood glucose, HbA1c levels, AR, SOD activity, NO and nerve conduction velocity were measured at the same time. The correlations among the above indexes were statistically analyzed. Results Linear regression analysis showed that nerve conduction velocity was significantly negatively correlated with blood glucose, HbA1c level and AR activity (P <0.01), and positively correlated with SOD activity and NO level (P <0.01) The conduction velocity was divided into three groups. There were significant differences in blood glucose, HbA1c, AR, SOD and NO between the two groups (P <0.01), but no significant difference between the two groups (P> 0.05). CONCLUSIONS: Hyperglycemia induced non-enzymatic glycation of protein and increased activity of polyol pathway. Oxidative stress plays an important role in the occurrence and development of early DN. NO may be involved in the formation of diabetic neuropathy