当患者从健康状态到罹患T2DM时,葡萄糖刺激的胰岛素分泌(GSIS)明显受损。尽管GISS主要是由胰岛β细胞对于血糖升高的直接感受所驱动,但有越来越多的证据表明,下丘脑神经元控制着外周葡萄糖代谢的其他方面。本文作者对大脑在GSIS的调节作用进行了研究。为了考察下丘脑葡萄糖感应增强或减弱对于葡萄糖耐量和胰岛素分泌 Glucose-stimulated insulin secretion (GSIS) is significantly impaired when the patient is healthy from T2DM. Although GISS is driven primarily by the direct perception of pancreatic beta cells for elevated blood glucose, there is growing evidence that hypothalamic neurons control other aspects of peripheral glucose metabolism. The authors studied the regulatory role of the brain in GSIS. In order to investigate whether hypothalamic glucose sensing enhances or attenuates glucose tolerance and insulin secretion