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目的探讨CD146蛋白在胰腺癌中的表达及其临床意义。方法选取60例胰腺癌组织和10例正常胰腺组织用免疫组织化学法检测其中CD146蛋白的表达,分析其与临床病理学特征的关系。结果 CD146蛋白在胰腺癌组织中的阳性表达率为83.33%,显著高于其在正常胰腺组织中的表达30.00%(P<0.01)。胰腺癌组织中CD146蛋白的高表达与肿瘤大小、淋巴结转移和临床分期有关(P<0.01)。结论 CD146蛋白与胰腺癌的恶性发展和转移有关。
Objective To investigate the expression of CD146 protein in pancreatic cancer and its clinical significance. Methods Sixty pancreatic cancer tissues and 10 normal pancreatic tissues were selected to detect the expression of CD146 protein by immunohistochemistry. The relationship between the expression of CD146 protein and clinicopathological features was analyzed. Results The positive rate of CD146 protein in pancreatic cancer tissues was 83.33%, which was significantly higher than that in normal pancreatic tissues (30.00%, P <0.01). The high expression of CD146 protein in pancreatic cancer correlated with tumor size, lymph node metastasis and clinical stage (P <0.01). Conclusion The CD146 protein is associated with the malignant development and metastasis of pancreatic cancer.