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硬脊膜外腔及椎管内用药是目前临床镇痛和麻醉药物的常用施药途径 ,在镇痛麻醉药物临床前研究中需要对动物施以硬脊膜外与椎管内置管手术以便进行药效与毒性研究。本研究室建立了一种实用于兔、犬、猴等较大动物的硬脊膜外及蛛网膜下腔的短期 (数天 )和长期 (数月 )置管方法。该方法结合临床穿刺和造影术定位 ,并根据动物的不同种类和差异进行适配和改进。上述置管法应用于虎纹镇痛肽 (HWAP- I)的临床前药效和毒理研究 ,经2 0 0多例次兔、犬和猴动物实验证明 ,这是一种定位准确稳定可靠的置管法。
Epidural and intraspinal administration is the common route of administration for clinical analgesia and narcotic drugs that require epidural and spinal canal catheterization in preclinical studies of analgesic anesthetics Study on Pharmacodynamics and Toxicity. Our laboratory has established a short-term (long-term) (several days) and long-term (several months) management of the epidural and subarachnoid space in larger animals such as rabbits, dogs and monkeys. The method combined with clinical puncture and angiography positioning, and according to different types of animals and differences to adapt and improve. The catheterization method used in tiger analgesic peptide (HWAP-I) preclinical efficacy and toxicological studies, more than 200 cases of rabbit, dog and monkey animal experiments show that this is a precise and reliable positioning The tube method.