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目的观察孟鲁司特钠治疗儿童轻、中度哮喘急性发作的疗效。方法 150例支气管哮喘患儿随机分为治疗组和对照组各75例。两组均予抗感染、止咳化痰平喘、布地奈德及沙丁胺醇雾化吸入等对症治疗。治疗组在此基础上加用孟鲁司特钠口服。结果治疗组总有效率100%,对照组97.33%,差异有统计学意义(χ2=7.204,P<0.01)。治疗组治疗后日间及夜间评分的改善均明显优于对照组,无明显不良反应发生。结论孟鲁司特钠是治疗儿童哮喘的一种安全、有效的方法。
Objective To observe the efficacy of montelukast sodium in treating acute exacerbation of mild and moderate asthma in children. Methods 150 cases of children with bronchial asthma were randomly divided into treatment group and control group of 75 cases. Both groups were anti-infective, cough and phlegm asthma, budesonide and salbutamol inhalation and other symptomatic treatment. On the basis of the treatment group, montelukast sodium was added orally. Results The total effective rate was 100% in the treatment group and 97.33% in the control group, the difference was statistically significant (χ2 = 7.204, P <0.01). After treatment, the treatment group improved the scores of day and night significantly better than the control group, no obvious adverse reactions occurred. Conclusion Montelukast is a safe and effective method for the treatment of childhood asthma.