尽管HIV-1的V3环可引发有效的中和抗体应答,但是抗体应答的特异性常局限于T细胞适应株(TCLA)和原代分离株小亚型,从而限制其作为艾滋病疫苗的使用。美国国立变态反应和传染病研究所Chakrabarti等对此进行了研究,观察V3环引起广泛中和抗体应答的能力,分两步进行:(1)异源序列引入 Although the V3 loop of HIV-1 elicits a potent neutralizing antibody response, the specificity of the antibody response is often confined to the T-cell adapter (TCLA) and small isolates of the primary isolate, limiting its use as an AIDS vaccine. The United States National Institute of Allergy and Infectious Diseases Chakrabarti et al. Conducted a study to observe the ability of the V3 loop to elicit a broadly neutralizing antibody response in two steps: (1) introduction of heterologous sequences