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目的:比较乳香和没药对大鼠的肝脏毒性。方法:48只Wistar大鼠随机分为4组,分别为对照组、乳香没药(1∶1)组、乳香组、没药组,各给药组剂量均为2.1 g.kg-1,连续ig 12周。禁食12 h后水合氯醛麻醉动物,取血检测血清生化指标,并解剖称取肝脏湿重计算肝脏系数,并测定肝组织中MDA含量,光镜下对肝脏进行病理组织学检查。结果:乳香没药组和乳香组大鼠的血清总胆固醇(TC)和肝组织中丙二醛(MDA)明显高于对照组(P<0.05)。给药组大鼠肝系数均明显升高(P<0.01),肝系数乳香组>乳香没药组>没药组。肝脏病理组织学检查表明,乳香组2只大鼠肝脏中度脂肪变性,而乳香没药组和没药组则未见明显异常。结论:乳香对大鼠的肝脏毒性强于没药。
Objective: To compare liver toxicity of frankincense and myrrh in rats. Methods: Forty-eight Wistar rats were randomly divided into 4 groups: control group, frankincense myrrh (1:1) group, frankincense group and myrrh group. The dose of each group was 2.1 g.kg-1. Ig 12 weeks. Animals were anaesthetized with chloral hydrate for 12 h after fasting. Blood samples were taken to detect serum biochemical indexes. Wet weight of liver was used to calculate the liver coefficient, and the content of MDA in liver tissue was measured. Histopathological examination of liver was performed under light microscope. RESULTS: Serum total cholesterol (TC) and malondialdehyde (MDA) in liver tissues were significantly higher in the frankincense myrrh group and the Mastic group than in the control group (P<0.05). The hepatic coefficient of the rats in the administration group was significantly increased (P<0.01), liver factor frankincense group> frankincense myrrh group> myrrh group. Liver histopathological examination showed moderate liver steatosis in the liver of 2 rats in the Frankincense group but no significant abnormalities in the Frankincense myrrh group and myrrh group. CONCLUSION: Boswellia serrata has more hepatotoxicity than myrrh in rats.