Increased expression of fascin associated with malignant transformation of sinonasal inverted papill

来源 :中华医学杂志(英文版) | 被引量 : 0次 | 上传用户:gold704
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Background Fascin, an actin binding protein, usually expressed at a low level in normal epithelium, but is significantly increased in transformed epithelial cells and several common carcinomas. In this study, we examined the expression of fascin by immunohistochemistry in sinonasal epithelium with chronic inflammation (control group), exophytic papilloma(EP), inverted papilloma (IP) with dysplasia and cancerated IP (including carcinoma in situ and invasive squamous cell carcinoma, SCC), and furthermore investigated the relationship between fascin expression and formation of malignant IP.Methods Fascin expression was immunohistochemically detected using monoclonal antibody against fascin in 86paraffin embedded tissues, including 10 cases of sinonasal mucosa with chronic inflammation, 10 of EP, 45 of IP with dysplasia (45 cases were divided into three groups: IP with mild dysplasia, IP with moderate dysplasia, and IP with severe dysplasia, 15 cases each), and 21 of cancerated IP.Results The level of fascin expression was significantly higher in the neoplastic tissue than that in control group. Fascin expression increased gradually with the progression from sinonasal epithelium with chronic inflammation, IP with mild dysplasia, IP with moderate dysplasia, IP with severe dysplasia, to cancerated IP, and significant difference of fascin expression was observed between any two groups of the five.Conclusion Precancerous lesions of IP exhibit elevated levels of fascin that may be associated with carcinogenesis of IP. Fascin may play a role in the formation of IP and EP.
其他文献
目的 探讨实时弹性成像引导的经会阴前列腺穿刺活检在提高前列腺癌检出率中的作用.方法 对108例因血清前列腺特异性抗原升高或直肠指检异常拟行前列腺穿刺活检的患者,在行实时弹性成像检查后行经直肠超声引导下经会阴穿刺活检术.穿刺方案采用10点系统穿刺加弹性成像异常处靶向穿刺,通过与前列腺穿刺病理作对照,研究追加弹性成像异常部位的靶向穿刺在提高前列腺癌检出率中的作用.结果 108例前列腺癌疑似患者经穿刺病
目的研究皮洗l号洗液的药物成分,药物质量控制标准,并探讨临床应用效果。方法对皮洗1号中药制剂,用薄层色谱法对所含的没食子酸、苦参碱进行鉴别。并设70例皮肤瘙痒症、急慢
阳春三月,桃红柳绿的杭州西湖畔鸟语花香,春意盎然,游人如潮……记者顾不得浏览西湖的美景,便踏进了座落在湖畔的大华饭店,在《上海造纸》杂志主编蒋荣祺的介绍下,采访了浙江
影响废纸油墨可脱除性的因素很多,既与废纸及印刷油墨的种类及特性、废纸的贮存状况等有关,也与所采用的脱墨方法、工艺流程及工艺条件密切相关。该文对影响油墨可脱除性的各
浆料中的空气是造成流送系统不稳定的最主要的原因之一,也是影响出纸质量的一个因素。浆料进湿部系统前必须考虑浆料的脱气。 The air in the slurry is one of the major c
目的 评价超声Flash技术联合声诺维(SonoVue)定向开放小鼠血脑屏障的可行性及安全性.方法 48只小鼠随机分为4组:空白组、微泡组、辐照组、超声辐照+微泡组,采用超声探头在Flash程序下联合静脉注射声诺维经颅骨定向辐照小鼠一侧基底节区,并利用伊文斯蓝示踪,荧光显微镜下观察脑组织中的伊文斯蓝荧光,定量分析脑组织伊文斯蓝浓度,并通过光镜和电镜观察脑组织大体细胞形态及超微结构改变.结果 空白组
目的分析金纳多治疗急性脑梗死患者血浆白细胞介素6(IL-6)和C-反应蛋白(CRP)的变化,探讨金纳多在急性缺血性脑血管病治疗中的相关机制。方法选择44例发病
结缔组织生长因子(CTGF)在糖尿病肾病(DN)发病过程中作为转化生因子-β(TGF-β)的下游调节因子,具有促进成纤维细胞活化以及细胞外基质产生、积聚等功能.现就CTGF的生物学特