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目的 探讨胃粘膜幽门螺杆菌 (Hp)感染与胃癌发生的关系。方法 采用免疫组化SP法检测基本正常胃粘膜 (对照组 ,3 0例 )、肠化生 ( 3 0例 )、不典型增生 ( 2 2例 )及胃癌 ( 2 5例 )组织中细胞核增殖抗原 (PCNA )的表达 ,采用快速尿素酶反应检测Hp感染情况。结果 PCNA表达与胃粘膜病变程度呈正相关 (γ =0 .65 5 ,P <0 .0 1) ;各组间Hp感染率无显著性差异 ,在肠化生及不典型增生组中Hp感染者的PCNA表达明显高于Hp阴性者 (P <0 .0 5 )。 结论 Hp感染可能通过影响细胞的增殖状况参与胃癌发生 ,其作用主要表现在癌前病变阶段。
Objective To investigate the relationship between gastric mucosal Helicobacter pylori (Hp) infection and gastric carcinogenesis. Methods Immunohistochemical SP method was used to detect the expression of nuclear proliferation antigen in normal gastric mucosa (control group, 30 cases), intestinal metaplasia (30 cases), atypical hyperplasia (22 cases) and gastric cancer (25 cases) (PCNA) expression, rapid urease test for detection of Hp infection. Results There was a positive correlation between the expression of PCNA and the degree of gastric mucosal lesions (γ = 0.655, P <0.01). There was no significant difference in the rate of Hp infection among the groups. In the group of intestinal metaplasia and atypical hyperplasia, PCNA expression was significantly higher than Hp negative (P <0.05). Conclusion Hp infection may be involved in the occurrence of gastric cancer by influencing the proliferation of cells, and its role mainly in the stage of precancerous lesions.