【摘 要】
：
The phenotype, DNA-binding activities of NF-κB, cytokine production, endocytosis and stimulatory capacity of spleen OX-62-positive dendritc cells (SDCs) from F
【机 构】
：
Immunology and Reproductive Biology Lab,Biological Engineering Lab
【基金项目】
：
the 985 Program of Nanjing University and the Key Medical Project Foundation of Jiangsu Province, Department of Health, China
论文部分内容阅读
The phenotype, DNA-binding activities of NF-κB, cytokine production, endocytosis and stimulatory capacity of spleen OX-62-positive dendritc cells (SDCs) from Fischer rats were compared with those from Lewis rats. Results showed that the expressions of CD11b, MHC-Ⅱ, CD8, CD45RA, CD54 and CD86 on SDCs were significantly higher in Fischer than those in Lewis rats. The levels of IL-2, IL-4, IL-10 and IFN-γ in SDCs from Fischer rats were distinctly higher than those from Lewis. Both stimulatory capacity and DNA-binding activities of NF-κB in SDCs were all lower in Fischer than those in Lewis rats. These differences may partly contribute to rat strainspecificity in susceptibility to chronic inflammatory stimuli.
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