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目的应用动态血压监测评价苯磺酸氨氯地平和氯沙坦对老年单纯收缩期高血压的降压疗效及谷峰比值(T/P)。方法60例老年单纯收缩期高血压患者随机分为2组.即氨氯地平组和氯沙坦组,各30例,分别眼药治疗8周,于治疗前后测定动态血压、诊室随测血压、心率、生化指标。结果治疗H周末。2组的诊室随测血压和24h、白昼及夜间平均收缩压、收缩压负荷值均显著降低(P<0.05),而心率则无明显变化。8周末。2组的降压总有效率分别为90%和93%。2组降压幅度比较差异无显著性(P>0.05)。降压T/P比值均大于50%。2组患者出现的不良反应均轻微。结论氨氯地平与氯沙坦均能平稳、有效、安全地降低老年单纯收缩期高血压。不良反应少,可作为老年单纯收缩期高血压的一线用药。
Objective To evaluate the antihypertensive effect and the ratio of peak to peak (T / P) of amlodipine besylate and losartan on isolated systolic hypertension in elderly patients by ambulatory blood pressure monitoring. Methods Sixty elder patients with isolated systolic hypertension were randomly divided into two groups: amlodipine group and losartan group, 30 cases each, treated with ophthalmic drugs for 8 weeks, ambulatory blood pressure was measured before and after treatment, Heart rate, biochemical indicators. Results Treatment H weekend. The systolic blood pressure (SBP) values of two clinics decreased significantly with blood pressure and 24h, daytime and nighttime systolic pressure (P <0.05), while heart rate did not change significantly. 8 weekend. The total effective rate of 2 groups was 90% and 93% respectively. There was no significant difference between the two groups (P> 0.05). Buck T / P ratio is greater than 50%. Adverse reactions were mild in both groups. Conclusion Both amlodipine and losartan can reduce elderly isolated systolic hypertension safely, effectively and safely. Adverse reactions, can be used as first-line treatment of elderly systolic hypertension.