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目的探索多环芳烃(PAHs)暴露对新生儿出生质量和生长发育的影响。方法随机抽取枣庄市257名在医院就诊或分娩的产妇,进行新生儿出生质量问卷调查,并采集新生儿脐带血用高效液相色谱-荧光检测法测定血清中7种PAHs的含量。依据总的PAHs水平,将新生儿分为高暴露组和低暴露组,探讨PAHs暴露对新生儿出生质量和新生儿生长发育的影响。结果脐带血中Pyrene芘和Benzo(a)pyrene苯并(a)芘[Pyr及B(a)P]的检出率较高(分别为92.18%和96.29%);B(k)F的检出率最低,为80.25%。将亚健康出生儿和出生缺陷儿合并单元格后统计发现,不同PAHs暴露水平之间的差异有统计学意义(χ2=3.933 9,P=0.047 3),不同PAHs暴露水平之间新生儿生长发育情况各总体构成比差异有统计学意义(χ2=7.976 0,P=0.018 5)。结论孕期暴露PAHs会影响胎儿的出生质量和生长发育。
Objective To explore the effects of polycyclic aromatic hydrocarbons (PAHs) exposure on newborn birth quality and growth. Methods A total of 257 maternal women who were hospitalized or given birth in Zaozhuang were randomly selected. The newborns’ birth quality questionnaires were collected and neonatal umbilical cord blood samples were collected. The levels of seven PAHs in serum were determined by high performance liquid chromatography-fluorescence detection. According to the total level of PAHs, newborns were divided into high-exposure group and low-exposure group to investigate the impact of PAHs exposure on newborn’s birth quality and newborn’s growth and development. Results The detection rates of Pyrene and B (a) P in cord blood were higher (92.18% and 96.29%, respectively) for Pyrene and Benzo (a) pyrene; The lowest rate is 80.25%. According to the statistics of merged cells between children with birth defects and those with birth defects, the differences in the exposure levels of different PAHs were statistically significant (χ2 = 3.9339, P = 0.047 3). The growth and development of newborns between different levels of PAHs exposure The overall composition of the situation difference was statistically significant (χ2 = 7.976 0, P = 0.018 5). Conclusion Exposure to PAHs during pregnancy affects the quality of birth and growth of the fetus.