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本文对小儿紫癜性肾炎30例,IgA肾病19例进行了临床病理及疗效比较。结果为:紫癜炎肾炎多表现为急性肾炎型(40％),肾病综合征型(46.7％);IgA肾病则多表现为慢性肾炎型(36.8％),肾病综合征型(31.6％)。病理分级:紫癜性肾炎Ⅱ级病变46.7％,Ⅲ级病变50％,Ⅳ级病变3.3％;IgA肾病Ⅱ级病变52.6％,Ⅲ级病变42.1％,Ⅳ级病变5.3％,紫癜性肾炎新月体形成为26.7％,IgA肾病为5.26％。免疫荧光镜检查均在系膜区有以IgA为主的弥漫沉积物,可伴有IgG,IgM,C_3,C_4,C_(1q)。疗效:紫癜性肾炎完全缓解80％,IgA肾病完全缓解68.4％,二者近期疗效无明显差异。
In this paper, 30 cases of children with purpura nephritis, IgA nephropathy in 19 cases were compared clinicopathological and efficacy. The results showed that most of the patients had purpura nephritis with acute nephritis (40%) and nephrotic syndrome (46.7%). The majority of IgA nephropathy showed chronic nephritis (36.8%) and nephrotic syndrome (31.6%). Pathological grade: Purpura nephritis Ⅱ grade lesions 46.7%, Ⅲ grade lesions 50%, Ⅳ grade lesions 3.3%; IgA nephropathy grade Ⅱ lesions 52.6%, Ⅲ grade lesions 42.1%, Ⅳ grade lesions 5.3%, purpura nephritis crescent shape As 26.7%, IgA nephropathy was 5.26%. Immunofluorescence microscopy in the mesangial area with IgA-based diffuse deposits, can be associated with IgG, IgM, C_3, C_4, C_ (1q). Efficacy: Purpura nephritis completely relieved 80%, IgA nephropathy completely relieved 68.4%, no significant difference between the two recent efficacy.