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目的观察并评价凯妮汀栓联合乳酸菌阴道胶囊治疗妊娠期外阴阴道假丝酵母菌病的疗效。方法研究第一阶段选择妊娠期首次确诊为外阴阴道假丝酵母菌病患者467例,分治疗组和对照组。治疗组(204例)联合使用凯妮汀栓、乳酸菌阴道胶囊;对照组(263例)仅使用凯妮汀栓。观察治疗1周后的疗效,及4周后复发情况。结果治疗组治疗1周后有效率为96.1%,4周后复发率为11.9%;对照组治疗1周后有效率为95.4%,4周后复发率为23.2%,两组比较治疗1周后有效率差异无统计学意义,4周后复发率差异有统计学意义。结论凯妮汀栓联合乳酸菌阴道胶囊治疗妊娠期外阴阴道假丝酵母菌病较单用凯妮汀栓治疗有相同的近期治疗效果,但有更低的远期复发率。
Objective To observe and evaluate the efficacy of Cunningidrine suppository combined with lactic acid bacteria vaginal capsule in the treatment of vulvovaginal candidiasis during pregnancy. Methods The first phase selected 467 cases of vulvovaginal candidiasis for the first time during pregnancy, divided into treatment group and control group. The treatment group (n = 204) was treated with Cinidin suppository and lactic acid bacteria vaginal capsule, while the control group (n = 263) used only cotinine suppository. Observed after 1 week of treatment efficacy, and 4 weeks after the recurrence. Results After 1 week of treatment, the effective rate was 96.1% and the recurrence rate was 11.9% after 4 weeks. In the control group, the effective rate was 95.4% after 1 week and 23.2% after 4 weeks. After 1 week of treatment, No significant difference in efficiency, recurrence after 4 weeks the difference was statistically significant. Conclusion The combination of CINTINE suppository and Lactobacillus vaginal capsule in the treatment of vulvovaginal candidiasis during pregnancy has the same short-term treatment effect as that of single-agent treatment with CINTIN, but has a lower long-term recurrence rate.