论文部分内容阅读
近十年来已证明血小板凝聚和血栓形成在缺血性心脏病综合征中具有病理生理上的重要性。因此阿斯匹林被广范地用于缺血性心脏病(IHD)的病人,而且近来又被推广于无临床表现的病人。本复习将审查阿斯匹林用于IHD的有关佐证。 1阿斯匹林对IHD效用的机制在血管损伤反应中血小板凝聚并释放粒状内含物,使血小板进一步凝聚和血管收缩,最后形成血栓。阿斯匹林阻滞血小板内血栓素A_2的合成,一种血管收缩性物质和血小板凝聚促进物质。虽然阿斯匹林抗血小板凝
Platelet aggregation and thrombosis have been shown to be pathophysiologically important in ischemic heart disease syndrome over the past decade. Aspirin is therefore widely used in patients with ischemic heart disease (IHD) and has recently been extended to non-clinical patients. This review examines the evidence of aspirin use in IHD. 1 The mechanism of aspirin’s utility in IHD Aggregation of platelets and release of granular inclusions during vascular injury reactions cause further platelet aggregation and vasoconstriction and eventually thrombus formation. Aspirin blocks platelet thromboxane A 2 synthesis, a vasoconstrictive substance and a platelet aggregation promoting substance. Although aspirin anti-platelet coagulation