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1970年印度报道闭花木甙(Cleistanthin—A)具有提高动物嗜中性白血球的作用,对由环磷酰胺和苯引起的白细胞减少症有明显升白作用,闭花木甙是热带荞木闭花木的树叶中分离得到的,我国尚未发现这种植物。北京制药工业研究所用半合成法试制了闭花木甙,由于工艺繁长,而且毒性较大,他们设想葡萄糖是机体正常生理代谢物质,若用它代替闭花木甙中的3,4-0-二甲基木糖,有可能保留其药理作用而降低毒性,并
1970 India reported that Cleistanthin-A has the effect of increasing neutrophil in animals, has a significant white effect on leukopenia caused by cyclophosphamide and benzene, and is a member of tropical buckwheat Isolated from the leaves, our country has not yet found this plant. Beijing Institute of Pharmaceutical Industry trial using semi-synthetic Clostridium glycosides, due to the long process, and more toxic, they assume that glucose is the body’s normal physiological metabolism of substance, if it is used instead of Clostridium 3,4-0-bis Methyl xylose, it is possible to retain its pharmacological effects and reduce toxicity, and