论文部分内容阅读
目的研究了环孢素A(CsA)在治疗难治性肾病综合征(RNS)上的效果。方法对38例RNS疾病的患者用CsA进行治疗,然后对其临床观察结果进行分析。男性患者有21例,女性患者有17例,按照每天2-5mg·Kg口服CsA,另加小剂量的激素0.4mg·Kg的泼尼松或者是甲泼尼松龙,整个疗程12个月,观察CsA治疗前后的变化。结果有32例(84.2%)患者的病情得到缓解,其中有26例(68.4%)患者的病情得到完全缓解,有6例(15.8%)患者的病情得到部分缓解,没有起到治疗效果的有5例(13.2%)。结论在治疗RNS时应用CsA并添加小剂量的激素是有效果的。
Objective To study the effect of cyclosporin A (CsA) in the treatment of refractory nephrotic syndrome (RNS). Methods Thirty-eight patients with RNS were treated with CsA, and then the clinical observation results were analyzed. There were 21 males and 17 females receiving oral CsA at a dose of 2-5 mg · kg per day plus prednisone at a low dose of 0.4 mg · Kg or methylprednisolone for 12 months, The changes of CsA before and after treatment were observed. RESULTS: Thirty-two (84.2%) patients were relieved of their disease, of which 26 (68.4%) had their disease completely relieved and 6 (15.8%) had their disease partially relieved and had no therapeutic benefit 5 cases (13.2%). Conclusion The application of CsA and the addition of small doses of hormones in the treatment of RNS are effective.