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目的 :探讨卵巢和子宫恶性肿瘤患者外周血染色体、腹水和实体瘤组织染色体改变与肿瘤临床分期愈后关系。结果 :2 0例恶性卵巢肿瘤和 10例子宫肿瘤外周血染色体分析 ,19例有染色体数目畸变 ,有超二倍体及异倍体 ,发生率 19/2 7;相应组织类型的良性肿瘤 30例 ,只有 3例出现染色体数目数畸变。实验组染色体数目畸变率明显高于对照组。P <0 .0 1。有染色体数目畸变的恶性肿瘤患者 ,无论临床转移或病理分级恶性程度都较高。
Objective: To investigate the relationship between chromosomal changes in chromosomes, ascites and solid tumor in patients with ovarian and uterine malignancies and the clinical stage of tumors. Results: Chromosome analysis of 20 cases of malignant ovarian tumors and 10 cases of uterine tumors showed that there were chromosome aberrations in 19 cases with hyper-diploid and aneuploidy, the incidence was 19/2 7. There were 30 benign tumors of the corresponding histological type , Only 3 cases appeared number of chromosome aberrations. The number of chromosome aberration in experimental group was significantly higher than that in control group. P <0 .0 1. Patients with malignant tumors with aberrations in chromosome number have high malignancy regardless of clinical metastasis or pathological grade.