测定了人体各种组织中与有机磷化合物代谢有关的二异丙基氟磷酸酯酶（ＤＦＰａｓｅ），对氧磷酶，乙酰胆碱酯酶（ＡＣｈＥ），丁酰胆碱酯酶（ＢＣｈＥ）及羧基酯酶（ＣａＥ）的活性水平．结果表明：在肾脏，脾脏和肝脏中含有丰富的ＤＦＰａｓｅ，可催化水解梭曼．其他组织该酶活性均很低．除人血清外，其他组织均未测到对氧磷酶活性．ＡＣｈＥ和ＢＣｈＥ主要分布于中脑，桥脑，延脑，纹状体及丘脑等脑干区域，另外肝脏中ＢＣｈＥ的比活性也较高．ＣａＥ主要分布于肝脏组织中，肺脏中也有较高的ＣａＥ活性．以上结果对了解有机磷化合物在人体中的中毒及代谢提供了一定的理论基础 DFPase, paraoxonase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carboxylate esters, which are involved in the metabolism of organophosphorus compounds in various tissues of the human body, Enzyme (CaE) activity levels. The results showed that DFPase is rich in kidney, spleen and liver, which can catalyze the hydrolysis of soman. Other tissues have low enzyme activity. No paraoxonase activity was detected in other tissues except human serum. AChE and BChE mainly distributed in the brain stem, pons, tubercle, striatum and thalamus and other brain stem areas, in addition, the specific activity of BChE in liver is also higher. CaE is mainly distributed in the liver tissue, and the lung also has higher CaE activity. The above results provide some theoretical basis for understanding the poisoning and metabolism of organophosphorus compounds in the human body