论文部分内容阅读
An efficient and novel method for synthesizing 3′,5′-dithio-2′-deoxyguanosine was described.In this method normal guanosine was used as the starting material.A very efficient procedure was used to synthesize 2-O-tosylguanosine 1,which used 0.1 eq.DBTO instead of 2 eq.1 was treated with LTBH to give 9-(2-deoxy-β-D-threo-pentofuranosyl)guanine 2.2 could be easily turned to the target compound.
An efficient and novel method for synthesizing 3 ’, 5’-dithio-2’-deoxyguanosine was described. This method normal guanosine was used as starting material. A very efficient procedure was used to synthesize 2-O-tosylguanosine 1, which used 0.1 eq. DBTO instead of 2 eq.1 was treated with LTBH to give 9- (2-deoxy-β-D-threo-pentofuranosyl) guanine 2.2 could be easily turned to the target compound.