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由于某些有机溶剂与环境污染和/或毒性问题有关,制药工业一直在探索替换以有机溶剂为基础的片剂包衣方法。市售的 Aquacoat和 Surelease 是生产上用于片剂包衣的乙基纤维素伪胶乳分散体的两种类型。Aquacoat 是一种通过十二烷基硫酸钠和十六烷醇稳定的乙基纤维素分散体,用于包衣前必须加入一种增塑剂。药物从 Aquacoat 包衣片中释放的机理是穿透聚合物包衣经扩散而释放,但包衣的片剂药物释放速率相当慢。为了使药物从片剂中渗透性地控释,应对市售的 Aquacoat 加以改良,加入水溶性的柠檬酸三乙酯(TEC)或
As some organic solvents are associated with environmental pollution and / or toxicity issues, the pharmaceutical industry has been exploring the replacement of organic solvent-based tablet coating methods. Commercially available Aquacoat and Surelease are two types of dispersion of ethylcellulose pseudo-latex for use in the manufacture of tablet coatings. Aquacoat is a stable ethylcellulose dispersion stabilized by sodium lauryl sulfate and cetyl alcohol and must be added with a plasticizer before coating. The mechanism of drug release from Aquacoat coated tablets is that the permeable polymer coating is released by diffusion but that the coated tablet drug release rate is relatively slow. In order to osmotically release the drug from the tablets, commercially available Aquacoats should be modified with the addition of water-soluble triethyl citrate (TEC) or