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为了定量控制β-内酰胺类抗生素产品中高分子杂质的含量,该文采用高效液相色谱法,以葡聚糖凝胶(Sephadex G-10)作为固定相,用自身对照外标法对头孢曲松钠高分子杂质进行了定量计算,结果表明缔合物在 Sephadex G-10凝胶系统中和高分子杂质具有相似的色谱行为,可精确对高分子杂质峰进行定量.“,”To control the polymer of the β-lactam antibiotics,we use HPLC method to detect its assay of ceftriaxone sodium.We use glucose gel as sta- tionary phase and calculating with external standard method.The result shows that the association of ce- triaxone sodium has the similar chromatographic be- havior as polymer.So we can use this method to do the quantitative analysis.