中性粒细胞在炎症部位的聚集是由多种不同来源的刺激分子所介导,包括C5a、血小板激活因子等,此外,我们和其它研究室还报导了一种新的多肽——中性粒细胞趋化因子(MDNCF),它是由LPS 或IL-1、TNF 激活外周血单核细胞或T 淋巴细胞、纤维母细胞、角质细胞和内皮细胞所产生。作者确定了其氨基末端的氨基酸序列、制备了CDNA 克隆、推断了整个氨基酸顺序并在 The accumulation of neutrophils in inflammatory sites is mediated by many different stimuli, including C5a and platelet activating factor. In addition, we and other laboratories also reported that a new polypeptide, neutrophil Cytokinin (MDNCF), which is produced by LPS or IL-1, TNF-activated peripheral blood mononuclear cells or T lymphocytes, fibroblasts, keratinocytes and endothelial cells. The authors identified the amino-terminal amino acid sequence of the cDNA and prepared a cDNA clone that deduced the entire amino acid sequence