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目的 :探讨蝮蛇抗栓酶在治疗结核性纤维化性胸腔积液中的作用。方法 :发生胸膜粘连肥厚明显趋势的结核性渗出性胸膜炎 6 1例 ,随机分为注药组 (2 8例 )和非注约组 (33例 ) ,注药组每次抽液后注入蝮蛇抗栓酶 0 .5U ,其他治疗措施两组相同。结果 :注药组抽液总量 (110 8± 32 8)ml,非注药组 (6 35± 2 81)ml(P <0 .0 1) ;注药组总有效率 89.3% ,非注药组 6 0 .6 % (P <0 .0 5 ) ;注药组胸膜肥厚发生率 5 0 .6 % ,非注药组 81.8% (P <0 .0 1) ,平均注药次数(3.6± 1.5 ) (2～ 8)次。结论 :在规则抗痨治疗下 ,胸腔内注入蝮蛇抗栓酶能显著增加胸液引流量 ,提高疗效 ,降低胸膜肥厚的发生。
Objective: To investigate the role of viper antithrombin in the treatment of tuberculous fibrotic pleural effusion. Methods Sixty-one cases of tuberculous exudative pleurisy with obvious tendency of hypertrophy of pleural adhesions were randomly divided into injection group (28 cases) and non-injection group (33 cases) Snake antithrombin 0 5U, the other treatment is the same in both groups. Results: The total amount of fluid extraction was (110 8 ± 32 8) ml in the injection group and (6 35 ± 2 81) ml in the non-injection group (P <0.01). The total effective rate was 89.3% (P <0.05). The incidence of pleural thickening in injection group was 56.6%, that in non-injection group was 81.8% (P <0.01), and the average number of injection was 3.6 ± 1.5) (2 ~ 8) times. Conclusion: In the regular anti-tuberculosis treatment, intrapleural injection of viper antithrombin can significantly increase the drainage of pleural fluid to improve efficacy and reduce pleural hypertrophy.