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本文探讨中枢注射组织胺（HA）增强胃酸分泌的作用机制。雄性SD大鼠重200～300g，用37℃生理盐水做恒速、连续胃灌流。膈下迷走神经切除后，观察第三脑室或外周给药对五肽促胃液素（G－5）诱导的胃酸分泌及对血浆皮质酮水平的影响。结果如下：（1）第三脑室注射1．0μg组织胺增强G－5诱导的胃酸分泌，这作用可为预先肌肉注射苯海拉明8．0μg所阻断。（2）脑室注射促肾上腺皮质激素释放因于（CRF，0.5μg，1．0μg）增强胃酸分泌，且呈量效关系。（3）脑室注射组织胺（1．0μg）提高血浆皮质酮水平。（4）静脉注射小剂量硫酸皮质酮增强胃酸分泌，也呈量效关系。上述结果提示：脑内组织胺H1受体和CRF参与胃酸分泌中枢调节的兴奋机制，传出途径可能与肾上腺释放皮质酮有关。
This article discusses the central injection of histamine (HA) to enhance the mechanism of gastric acid secretion. Male SD rats weight 200 ~ 300g, with 37 ℃ normal saline to do constant gastric perfusion. Subdiaphragmatic vagotomy was performed to observe the effect of the third ventricle or peripheral administration on gastric acid secretion induced by pentagastrin (G-5) and plasma corticosterone level. The results were as follows: (1) A third intracerebroventricular injection of 1.0 μg of histamine enhanced G-5-induced gastric acid secretion, which was blocked by pre-intramuscular injection of diphenhydramine 8.0 μg. (2) The intracerebroventricular injection of adrenocorticotropic hormone enhances gastric acid secretion due to (CRF, 0.5μg, 1.0μg) and has a dose-effect relationship. (3) Intraventricular injection of histamine (1.0μg) increased plasma corticosterone levels. (4) intravenous injection of low-dose corticosterone enhances gastric acid secretion, also showed a dose-effect relationship. These results suggest that: the brain histamine H1 receptor and CRF involved in gastric acid secretion central regulation of excitatory mechanism, the outgoing path may be related to the adrenal corticosterone release.