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目的:观察生长抑素联合泮托拉唑在治疗肝硬化并发上消化道大出血止血治疗中的疗效。方法:随机将136例患者分为治疗组(n=68)和对照组(n=68),治疗组应用生长抑素联合泮托拉唑治疗,先应用生长抑素250μg静脉推注,然后以250μg/h的速度持续微量泵滴入,维持48～72 h;泮托拉唑40mg加入生理盐水100 ml中静脉滴注,2次/d,维持48～72 h。对照组单用生长抑素治疗,先生长抑素250μg静脉推注,然后250μg/h持续微量泵注射,维持48～72 h,观察各组治疗效果。结果:治疗组治疗总有效率为97.06%,高于对照组的85.30%,差异有统计学意义(P<0.05)。结论:生长抑素联合泮托拉唑是治疗肝硬化上消化道大出血的有效措施之一,疗效优于单用生长抑素的止血效果,且副作用小,值得临床推广,更适合基层医院临床应用。
Objective: To observe the efficacy of somatostatin combined with pantoprazole in the treatment of cirrhosis complicated by upper gastrointestinal hemorrhage. Methods: 136 patients were randomly divided into treatment group (n = 68) and control group (n = 68). The treatment group was treated with somatostatin and pantoprazole. The patients were initially given 250μg intravenous infusion of somatostatin 250μg / h continuous micro-pump infusion, maintained 48 ~ 72h; pantoprazole 40mg added 100ml of saline intravenously, 2 times / d, maintained for 48 ~ 72h. The control group was treated with somatostatin only. The first somatostatin 250μg intravenous injection, then 250μg / h continuous micro-pump injection, maintained for 48 ~ 72 h, the treatment effect was observed in each group. Results: The total effective rate of the treatment group was 97.06%, which was higher than that of the control group (85.30%), the difference was statistically significant (P <0.05). Conclusion: Somatostatin combined with pantoprazole is one of the effective measures for the treatment of upper gastrointestinal hemorrhage in cirrhosis. The effect is better than the hemostatic effect of somatostatin alone. The side effect is small and worthy of clinical promotion, which is more suitable for the clinical application of primary hospital .