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目的：检测急性胰腺炎患者止凝血指标的变化。方法：２６例急性胰腺炎患者分为轻型组和重型组，测定抗凝血酶Ⅲ（ＡＴⅢ）、血管性假血友病因子（ｖＷＦ）、血小板颗粒膜蛋白（ＧＭＰ１４０）、组织纤溶酶原（Ｐｌｇ）、纤溶酶原激活物（ｔＰＡ）、纤溶酶原激活物抑制剂（ＰＡＩ）、交联纤维蛋白降解产物（ＤＤ）。采用方差分析和ｑ检验。结果：ＧＭＰ１４０、ｖＷＦ值升高，Ｐｌｇ活性下降，重型组变化更显著（Ｐ＜０．０１），并有ＡＴⅢ、ｔＰＡ活性下降和ＰＡＩ活性的升高（Ｐ＜０．０１）。结论：急性胰腺炎患者存在凝血和纤溶系统的激活，血小板和血管内皮细胞受损，重型组伴有纤溶受抑，凝血、纤溶失衡，血液呈高凝状态。
Objective: To detect the change of blood coagulation index in patients with acute pancreatitis. Methods: Twenty-six patients with acute pancreatitis were divided into mild group and severe group. The levels of antithrombin Ⅲ (ATⅢ), von Willebrand factor (vWF), platelet membrane protein (GMP140) Plasminogen (Plg), plasminogen activator (t PA), plasminogen activator inhibitor (PAI), cross-linked fibrin degradation products (D D). Analysis of variance and q test. Results: The GMP140, vWF value increased, Plg activity decreased, the changes in severe group more significant (P <0.01), and AT Ⅲ, t PA activity decreased and PAI activity increased (P <0. 01). CONCLUSIONS: There is coagulation and fibrinolysis activation in patients with acute pancreatitis, impaired platelet and vascular endothelial cells, fibrinolytic suppression, coagulation and fibrinolysis in the severe group and hypercoagulability in the blood.