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目的探讨正常妊娠妇女不同孕期肝功能指标的变化及临床意义。方法采用日本东芝TBA40FR型型全自动生化分析仪,检测1500例不同孕期的正常妊娠妇女主要的肝功能指标,并与80例正常非妊娠妇女作比较。结果妊娠组ALT、AST、TP、ALB、ALP、LDH和CK的水平变化在不同孕期有不同程度的改变,晚期改变明显,与正常对照组比较有显著性差异(p<0.01);GGT、T-BIL、D-BIL的水平变化与正常对照组比较无统计学意义(p>0.05)。结论正常妊娠妇女不同孕期肝功能指标较正常非妊娠妇女有明显变化,测定这些指标对妊娠期的保健有一定的临床意义。
Objective To investigate the changes and clinical significance of liver function indexes in different pregnant women during normal pregnancy. Methods TOSHIBA Model TBA40FR automatic biochemical analyzer was used to detect the main liver function indexes of 1 500 pregnant women of different gestational ages and compared with 80 normal non-pregnant women. Results The levels of ALT, AST, TP, ALB, ALP, LDH and CK in pregnancy group changed to different degrees in different stages of pregnancy, and the changes in late stage were significantly different from those in normal control group (p <0.01). The levels of GGT, T The level changes of BIL and D-BIL were not statistically significant compared with the normal control group (p> 0.05). Conclusion The normal pregnant women have different changes of liver function index in different stages of pregnancy than normal non-pregnant women. The determination of these indexes has some clinical significance in the pregnancy.