论文部分内容阅读
目的探讨MMP1、MMP2、MMP9与TIMP-1、TIMP-2在脑胶质瘤患者中的表达及检测对脑胶质瘤的临床诊断价值。方法对诊治的38例脑胶质瘤患者及20例非肿瘤颅脑手术患者的脑组织进行MMP1、MMP2、MMP9与TIMP-1、TIMP-2表达检测。结果正常对照组非肿瘤患者中,MMP1、MMP2、MMP9未见表达,1例患者存在TIMP-1、TIMP-2表达(+),脑胶质瘤患者中,MMP1、MMP2、MMP9、TIMP-1、TIMP-2表达阳性率分别为60.53%、60.53%、65.79%、57.90%、55.26%,并且随着生物学分级级别增高表达阳性率亦呈现增高趋势;低级别组(I级+Ⅱ级)MMP1、MMP2、MMP9、TIMP-1、TIMP-2表达阳性率低于高级别组(Ⅲ级+IV级),差异有统计学意义(P﹤0.05);Speaman相关性分析MMP1、MMP2、MMP9、TIMP-1、TIMP-2与脑胶质瘤的恶性程度具有正相关(r=0.2517～0.6211,P﹤0.05)。结论 MMP1、MMP2、MMP9、TIMP-1、TIMP-2与脑胶质瘤的生长具有相关性,并且能反映出恶性程度及其侵袭能力,联合检测对于医师判断脑胶质瘤的恶性程度及其侵袭能力有一定的临床价值。
Objective To investigate the expression of MMP1, MMP2, MMP9, TIMP-1 and TIMP-2 in glioma patients and the clinical value of their detection in gliomas. Methods The expressions of MMP1, MMP2, MMP9, TIMP-1 and TIMP-2 in brain tissue of 38 patients with glioma and 20 patients with non-tumor cranial surgery were detected. Results There was no expression of MMP1, MMP2 and MMP9 in non-tumor patients of normal control group. There was expression of TIMP-1 and TIMP-2 in one patient (+), and expression of MMP1, MMP2, MMP9 and TIMP- , And the positive rates of TIMP-2 expression were 60.53%, 60.53%, 65.79%, 57.90% and 55.26%, respectively. The positive rate of TIMP-2 was also increased with the increase of biological grade. The positive rates of MMP1, MMP2, MMP9, TIMP-1 and TIMP-2 were lower than those in the high-grade group (grade Ⅲ + Ⅳ) (P <0.05) TIMP-1 and TIMP-2 had positive correlation with the malignant degree of glioma (r = 0.2517-0.6211, P <0.05). Conclusions MMP1, MMP2, MMP9, TIMP-1 and TIMP-2 have correlation with the growth of glioma and can reflect the degree of malignancy and invasiveness. The combined detection of physician judgment of malignant glioma and its Invasive ability to a certain degree of clinical value.