目的:观察注射用丹参多酚酸盐联合常规西药治疗慢性心力衰竭(CHF)的疗效。方法:选择70例CHF患者,随机分为治疗组与对照组各35例。对照组予强心利尿和扩张血管等常规抗心衰治疗,治疗组在对照组治疗基础上加用注射用丹参多酚酸盐治疗,2组均连用14天。观察2组治疗前和治疗14天后血清B型脑钠肽(BNP)水平及左心室功能指标的变化,并比较临床疗效。结果:治疗14天后,治疗组总有效率高于对照组(P<0.05)。2组血清BNP水平均较治疗前下降(P<0.05,P<0.01),治疗组血清BNP水平低于对照组(P<0.05)。2组LVEDD、LVESD均较治疗前下降,LVEF均较治疗前上升,差异均有统计学意义(P<0.05),治疗组3项指标较对照组下降或上升更明显(P<0.05)。结论:注射用丹参多酚酸盐辅助常规西药治疗CHF的疗效较显著,可降低左心室负荷,减少BNP的分泌,从而降低血清BNP水平,改善心功能。 Objective: To observe the curative effect of Salviae miltiorrhizae polyphenols injection and conventional western medicine on chronic heart failure (CHF). Methods: Seventy patients with CHF were randomly divided into treatment group (35 cases) and control group (35 cases). The control group was given cardiac antidiarrheal and dilatation of blood vessels and other conventional anti-heart failure treatment. The treatment group was treated with Salviae miltiorrhizae polyphenols injection on the basis of the control group, both of which were used for 14 days. The changes of serum B-type natriuretic peptide (BNP) level and left ventricular function before and 14 days after treatment were observed in two groups, and the clinical curative effect was compared. Results: After 14 days of treatment, the total effective rate of the treatment group was higher than that of the control group (P <0.05). Serum BNP levels in both groups were significantly lower than those before treatment (P <0.05, P <0.01). Serum BNP levels in the treatment group were lower than those in the control group (P <0.05). LVEDD and LVESD in both groups were significantly lower than before treatment and LVEF were higher than those before treatment (P <0.05). The three indexes in the treatment group decreased or increased more significantly than those in the control group (P <0.05). Conclusion: Salviae miltiorrhizae is effective in the treatment of CHF by conventional western medicine, which can reduce left ventricular load, decrease BNP secretion, lower serum BNP level and improve heart function.