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在头颈部肿瘤治疗中,多种综合治疗方案已被应用于临床。如术前和/或术后放疗,术前和/或术后化疗,手术加化疗和放疗等。综合治疗的疗效和生存率比单一疗法都有不同程度的提高,但时于有些晚期头颈部癌瘤,即使无颈淋巴结转移,手术切除的治愈率也只有20%,对难于切除的肿瘤,由于其缺氧的细胞多,对放疗和化疗均不敏感,故单独化疗或放疗难于奏致。近十年来,人们在探索同期应用化疗和放疗的综合疗法,以增强杀灭肿瘤细胞的作用。然而已经用博莱霉素(BLM),氟脲嘧啶(5-FU)或氨甲喋呤(MTX)等化疗药物同期配合放疗,经临床证明,疗效提高并不明显。Oconnor等
In the treatment of head and neck cancer, a variety of comprehensive treatment programs have been applied to the clinic. Such as preoperative and / or postoperative radiotherapy, preoperative and / or postoperative chemotherapy, surgery plus chemotherapy and radiotherapy. The efficacy and survival rate of comprehensive treatment have been improved to a different extent than that of monotherapy. However, in some advanced head and neck cancers, even if there is no cervical lymph node metastasis, the cure rate for surgical resection is only 20%. For difficult-to-remove tumors, Because of its many hypoxic cells, it is not sensitive to radiotherapy and chemotherapy, so it is difficult to play alone chemotherapy or radiotherapy. In the past decade, people have been exploring the use of combination chemotherapy and radiotherapy in the same period to enhance the killing of tumor cells. However, chemotherapeutic agents such as BLM, 5-FU or MTX have been used in combination with radiotherapy at the same time. Clinically proven efficacy has not been significantly improved. Oconnor et al.