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目的考察芒果叶提取物马来酸酐7-2-4-2-2(iriflophenone 3-c-β-D-glucoside,MAH 7-2-4-2-2)大鼠的在体肠吸收动力学性质。方法采用大鼠在体单向灌流法,利用HPLC法测定MAH 7-2-4-2-2的含量,分别研究吸收部位、药物浓度对MAH 7-2-4-2-2吸收的影响。结果小肠段间药物的吸收速率常数ka和表观吸收系数Papp比较均无明显差异(P>0.05);小肠段与结肠段药物吸收速率常数,表观吸收系数Papp之间均存在显著性差异(P<0.05);质量浓度在5.15～102.90 mg·L-1内,吸收速率常数ka和表观吸收系数Papp比较均无明显差异(P>0.05)。结论 MAH 7-2-4-2-2在全肠道均有吸收;吸收无高浓度饱和现象,提示MAH 7-2-4-2-2吸收可能为被动扩散机制。
Objective To investigate the in vivo intestinal absorption kinetics of mangrove leaf extract maleic anhydride 7-2-4-2-2 (iriflophenone 3-c-β-D-glucoside, MAH 7-2-4-2-2) nature. Methods The content of MAH 7-2-4-2-2 was determined by HPLC in rat by one-way perfusion in vivo. The effects of absorption site and drug concentration on the absorption of MAH 7-2-4-2-2 were studied. Results There was no significant difference in the absorption rate constant ka and the apparent absorption coefficient Papp between the intestinal segments (P> 0.05). There was a significant difference between the absorption rate constant and the apparent absorption coefficient Papp in the small intestine and the colon P <0.05). The mass concentration ranged from 5.15 to 102.90 mg · L-1. There was no significant difference between the absorption rate constant ka and the apparent absorption coefficient Papp (P> 0.05). Conclusion MAH 7-2-4-2-2 is absorbed in the whole intestine. Absorption is not saturated at high concentration, suggesting that the MAH 7-2-4-2-2 absorption may be a passive diffusion mechanism.