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目的探讨扶正散结汤临床用药剂量与疗效和不良反应的关系。方法将88例晚期肝癌患者随机分为大、中、小三个剂量组,每日服3次,4周为1个周期,共服用2个周期,观察疗效和不良反应。结果大、中剂量对晚期肝癌患者皆具有明显的治疗效果,疗效与用药剂量大小成正相关,具有明显的剂量、效应关系,适宜于肝郁气滞型、血瘀型、脾虚湿困型及湿热蕴毒型晚期肝癌患者的治疗,能提高患者的生活质量,延长生存时间,缩小瘤体,增加体质量,并能提高患者免疫功能;大、中、小剂量组不良反应发生率比较差异无统计学意义,反应轻微且共性差。结论扶正散结汤治疗晚期肝癌具有明显治疗效果,疗效与用药剂量大小成正相关,临床使用无明显不良反应。
Objective To investigate the relationship between the dosage of Fuzheng Sanjie Decoction and its curative effect and adverse reactions. Methods Eighty-eight patients with advanced liver cancer were randomly divided into three groups: large, medium, and small doses. They were given 3 times a day, 4 cycles were 1 cycle, and 2 cycles were taken. The curative effects and adverse reactions were observed. Results Large and middle doses all had significant therapeutic effects on patients with advanced hepatocellular carcinoma. The efficacy was positively correlated with the size of the doses. It had a significant dose-effect relationship and was suitable for liver qi stagnation, blood stasis, spleen deficiency, and wet heat. The treatment of patients with advanced toxic hepatic cancer can improve the quality of life of patients, prolong survival time, reduce tumor size, increase body weight, and improve the immune function of patients; the incidence of adverse reactions in large, medium and small dose groups has no statistical difference Academic significance, slight reaction and poor commonality. Conclusion Fuzheng Sanjie decoction has obvious curative effect on the treatment of advanced hepatocellular carcinoma. The curative effect is positively correlated with the dosage of the drug. There is no obvious adverse reaction in clinical use.