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目的 :观察 4 0例患者服用早孕酮后改善化疗所致的厌食和体重下降的疗效 ,并进行对比研究。方法 :4 0例接受化疗的晚期消化道肿瘤患者随机分为两组 ,治疗组 2 0例 (化疗 +甲孕酮 ) ,对照组 2 0例 (单用化疗 ) ,对比观察两组食欲、体重及生活质量的改善情况。结果 :治疗组食欲改善占 6 0 % ,体重增加占 70 % ,Karnofsky分值提高占 6 0% ,明显优于对照组 (P <0 .0 1)。服用甲孕酮期间 10 %的患者阴道出血 ,15 %轻度浮肿 ,5 %血糖轻度升高 ,均可逆。结论 :甲孕酮如能正确合理地用于晚期癌症的治疗 ,可以全面改善化疗期癌症患者的生活质量。
Objectives: To observe the effect of anorectic and weight loss caused by chemotherapy after taking progesterone in 40 patients, and conduct a comparative study. Methods: Forty patients with advanced gastrointestinal cancer undergoing chemotherapy were randomly divided into two groups: 20 patients in the treatment group (chemotherapy plus medroxyprogesterone) and 20 patients in the control group (single use of chemotherapy). The appetite and body weight were compared between the two groups. And the improvement of the quality of life. Results: The appetite improvement in the treatment group accounted for 60%, weight gain accounted for 70%, Karnofsky score increased by 60%, which was significantly better than that in the control group (P < 0.01). Vaginal bleeding, 15% mild edema, and 5% mildly elevated plasma glucose were reversible in 10% of patients taking medroxyprogesterone. Conclusion: If progesterone is used correctly and reasonably in the treatment of advanced cancer, it can improve the quality of life of cancer patients during chemotherapy.