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目的 :利用碳 14氨基比林呼气试验 (C1 4 - ABT)对肝炎后肝硬化患者的肝贮备功能进行检测 ,以了解其实验对肝硬化预后的意义。方法 :患者清晨空腹口服 1粒 C1 4标记氨基比林胶囊 (标记量 37k Bq) ,2 h后定量收集患者呼出的 CO2 ,再通过仪器检测其中 C1 4的活性 ,从而计算出其代谢率。结果 :肝硬化代偿和失代偿患者 C1 4 - ABT结果有明显差异 ,C1 4 - ABT与血清胆红素水平呈轻度负相关 ,与血清白蛋白相关性不大 ,而与球蛋白呈高度负相关。C1 4 - ABT与谷丙转氨酶 (AL T)无明显相关 ,而与谷草转氨酶 (AST)呈负相关。 C1 4 - ABT与凝血酶原活动度呈正相关 ,而与凝血酶原时间负相关。C1 4 - ABT结果 <1%的患者 3个月内均无一存活。结论 :C1 4 - ABT对肝硬化患者肝贮备功能的评价是一项非常有意义的指标 ,对患者的预后也有一定指导意义。
OBJECTIVE: To evaluate the liver function of patients with posthepatitic cirrhosis by carbon 14 aminopyrine breath test (C1 4 - ABT) to understand the significance of the experiment on the prognosis of liver cirrhosis. Methods: The patients were given 1 C14 aminopyrine capsules (labeled 37k Bq) in fasting morning and then the exhaled carbon dioxide (CO2) was collected 2 hours later, and the activity of C1 4 was detected by the instrument to calculate the metabolic rate. Results: The results of C1 4 - ABT in patients with decompensated and decompensated liver cirrhosis were significantly different. C1 4 - ABT was slightly negatively correlated with serum bilirubin level, but not with serum albumin, but with globulin Highly negative correlation. C1 4 - ABT had no significant correlation with ALT, but negatively correlated with aspartate aminotransferase (AST). C1 4 - ABT was positively correlated with prothrombin activity, but negatively correlated with prothrombin time. None of the patients with C1 4-ABT results <1% survived within 3 months. Conclusion: The evaluation of C1 4 - ABT in patients with liver cirrhosis is a very meaningful indicator of liver function, and has some guiding significance for the prognosis of patients.