论文部分内容阅读
目的研究非磺脲类促泌剂对进食实验餐后的心血管危险因子的作用。方法14例初次单纯饮食控制的2型糖尿病患者经过2周的清洗期,然后进入为期3个月的随机、交叉、平行瑞格列奈(1mg,2次/日)和格列美脲(2mg,1次/日)实验。与磺脲类相比,非磺脲类促泌剂治疗能使进食试验餐后120分钟时的血浆葡萄糖、TG、游离脂肪酸、纤维蛋白原、PAI—1、纤溶酶—a(2)—抗纤溶酶复合物(PAP)、凝血酶—抗凝血酶复合物以及TBARS水平显著降低,而血浆HDL升高。结果与磺脲类促泌剂相比,非磺脲类促泌剂治疗能显著降低游离脂肪酸(r=0.62;P<0.01)、纤维蛋白原、PAI—1(r=0.72;P<0.003)、PAP、凝血酶—抗凝血酶复合物以及TBARS水平,HDL胆固醇增高。结论非磺脲类促泌剂可能对降低心血管危险因素具有裨益。
Objective To investigate the effect of non-sulfonylurea secretions on post-prandial cardiovascular risk factors in rats. Methods Fourteen patients with type 2 diabetes mellitus undergoing primary diet control were enrolled in a randomized, crossover, parallel repaglinide (1 mg, 2 / day) and glimepiride (2 mg , 1 time / day) experiment. Compared with sulfonylureas, non-sulfonylurea secretagogues treated plasma glucose, TG, free fatty acids, fibrinogen, PAI-1, plasmin-a (2) Anti-plasmin complex (PAP), thrombin-antithrombin complex and TBARS levels were significantly reduced, while plasma HDL was elevated. Results Compared with sulfonylureas, the non-sulfonylurea secretagogues treatment significantly reduced free fatty acids (r = 0.62; P <0.01), fibrinogen, PAI-1 , PAP, thrombin-antithrombin complex, and TBARS levels, increased HDL cholesterol. Conclusions Non-sulfonylurea secretagogues may be helpful in reducing cardiovascular risk factors.