目的:探讨垂体后叶素在难治性宫颈炎电圈切除(LEEP)术中的止血效果。方法:90例难治性宫颈炎患者随机分成3组,均采用LEEP环形电切术。术中A组(n=30)于宫颈6°、12°注射生理盐水2 mL;B组(n=30)于宫颈6°、12°注射垂体后叶素3 U+生理盐水的混合液2 mL;C组(n=30)于宫颈6°、12°注射垂体后叶素6 U+生理盐水的混合液2 mL。比较3组手术时间、术中出血量、切割深度及不良反应发生情况的差异。结果:手术时间:A组为(12.41±1.80)min,B组为(7.38±2.10)min,C组为(6.45±1.81)min,A组比B、C组明显延长(P<0.001),B组与C组差异无显著性(P>0.05);术中出血量:A组为(10.25±2.46)mL,B组为(6.68±1.58)mL,C组为(5.95±1.32)mL,A组比B、C组均明显增多(P<0.01),B组与C组差异无显著性(P>0.05);切割深度:A组为(6.86±1.27)mm,B组为(7.21±1.12)mm,C组为(7.13±1.17)mm,3组比较差异无显著性(P>0.05);不良反应:A组1例,B组2例,C组9例,A组与B组明显少于C组(P<0.005),A组与B组差异无显著性(P>0.05)。结论:半量垂体后叶素宫颈注射可以减少LEEP术中的出血量及手术时间,减少不良反应的发生。 Objective: To investigate the effect of pituitrin in the treatment of refractory cervicitis (LEEP). Methods: 90 patients with refractory cervicitis were randomly divided into 3 groups, all using LEEP ring resection. Group B (n = 30) was injected with 2 mL of pituitrin 3 U + saline solution at 6 ° in the cervix and 12 ° in the group A (n = 30) ; Group C (n = 30) in the cervix 6 °, 12 ° injection pituitrin 6 U + saline mixture 2 mL. The differences of operation time, intraoperative blood loss, depth of cut and incidence of adverse reactions were compared between the three groups. Results: The time of operation was (12.41 ± 1.80) min in group A, (7.38 ± 2.10) min in group B, and 6.45 ± 1.81 min in group C (P <0.001) There was no significant difference between group B and group C (P> 0.05). The amount of intraoperative blood loss was (10.25 ± 2.46) mL in group A, (6.68 ± 1.58) mL in group B and (5.95 ± 1.32) mL in group C (P> 0.05). The depth of resection was (6.86 ± 1.27) mm in group A and (7.21 ±) mm in group B compared with that in group B and C (P <0.01) 1.12) mm in group C, and (7.13 ± 1.17) mm in group C, with no significant difference between the three groups (P> 0.05). Adverse reactions were as follows: group A in 1, group B in 2, group C in 9, group A and group B (P <0.005). There was no significant difference between group A and group B (P> 0.05). Conclusion: The injection of semi-pituitrin into cervix can reduce the amount of bleeding and operation time during LEEP, and reduce the incidence of adverse reactions.