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目的:通过分析住院患者服用丙戊酸后生化及血常规指标变化,探究丙戊酸对患者体内生化指标的影响,为临床安全用药提供依据。方法:利用医院HIS系统提取2008—2013年6年期间曾在北京医院住院且服用过丙戊酸的患者信息,包括基本信息、检验信息和医嘱信息,并对这些信息进行汇总分析。结果:在6年间住院且服用丙戊酸的患者共计893人次(731人),呈逐年增加的趋势;年龄在10~95岁范围内,且70~79岁居多;入院诊断大多为癫痫并入住神经科。这类患者在住院期间,生化及血常规指标呈异常变化趋势。其中血清白蛋白、红蛋白、红细胞均有不同程度的降低,血钾、钠、氯和钙离子的检验值降低的程度不等;尿素氮和谷草转氨酶升高,而白细胞、尿酸、谷丙转氨酶和淀粉酶的变化可能与其他因素有关。结论:长期服用丙戊酸的患者需密切关注以上生化检验指标的变化。
Objective: To analyze the influence of valproic acid on the biochemical indexes in patients by analyzing the changes of biochemical and hematological indexes after taking valproic acid in hospitalized patients, and provide the basis for clinical safety medication. Methods: The hospital HIS system was used to extract the information of patients who had been hospitalized in Beijing Hospital during the 6 years from 2008 to 2013 and who had taken valproic acid, including the basic information, test information and medical order information. The information was summarized and analyzed. Results: A total of 893 hospitalized patients (731) were hospitalized with valproic acid within 6 years, showing a trend of increasing year by year. The age ranged from 10 to 95 years and mostly ranged from 70 to 79 years. Admissions were mostly epilepsy and admitted Neurology. Such patients during hospitalization, biochemical and blood indicators showed an abnormal trend. Serum albumin, hemoglobin, red blood cells were reduced to varying degrees, serum potassium, sodium, chlorine and calcium levels decreased to varying degrees; urea nitrogen and aspartate aminotransferase increased, and leukocytes, uric acid, alanine aminotransferase And amylase changes may be related to other factors. Conclusion: Long-term use of valproic acid patients should pay close attention to the above biochemical test indicators of change.