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正性肌力药物能影响心肌收缩力,是治疗心力衰竭的主要药物之一,用于治疗心力衰竭的药物疗效及用药患者终期生存率取决于作用靶点。与心肌收缩力有关的靶点包括:β肾上腺素受体、磷酸二酯酶、L-型钙通道、蛋白激酶A、蛋白激酶C、蛋白磷酸酶、Na+-Ca2+交换体、Na+-K+-ATP酶、肌浆网钙泵、受磷蛋白、兰尼碱受体、三磷酸肌醇受体、与钙增敏剂相关的心肌收缩蛋白等。文中对心肌收缩力相关的作用靶点进行综述,分析临床现今使用的和未来的正性肌力药物应具备的靶点特征。
Inotropic drugs can affect myocardial contractility, is the treatment of heart failure, one of the main drugs used to treat heart failure drug efficacy and drug use in patients with end-stage survival depends on the target. Targets involved in myocardial contractility include beta adrenergic receptor, phosphodiesterase, L-type calcium channel, protein kinase A, protein kinase C, protein phosphatase, Na + -Ca2 + exchanger, Na + -K + -ATP Enzyme, sarcoplasmic reticulum calcium pump, phospholamban, ryanodine receptor, inositol trisphosphate receptor, and myocardial contractile proteins associated with calcium sensitizers. In this paper, we reviewed the targets of myocardial contractility, and analyzed the target characteristics that should be used in clinical present and future inotropes.